R&D dynamics and scientific breakthroughs in HIV/AIDS drugs development: the case of Integrase Inhibitors

J. J. Winnink () and Robert J. W. Tijssen
Additional contact information
J. J. Winnink: Leiden University
Robert J. W. Tijssen: Leiden University

Scientometrics, 2014, vol. 101, issue 1, No 1, 16 pages

Abstract: Abstract Transformations and applications of scientific knowledge into new technologies are usually complex interactive processes. Is it possible to detect, from bibliographic information alone, structural alterations and significant events within these processes that may indicate breakthrough discoveries? In this empirical study we focus on R&D processes leading to HIV/AIDS medicines called Integrase Inhibitors. Where scientific progress and discoveries are reflected in research papers, patents signify inventions and technological achievements. Our temporal analysis of distinctive events in this R&D area, tracing trends within both bibliographic information sources, is driven by three bibliometric indicators: (1) contributions of ‘bridging researchers’ who are also inventors, (2) ‘key papers’ that subject experts in the field considered milestones in the research process, and (3) the multidisciplinary impact of those papers. The main results indicate that a combination of key papers, bridging researchers and multidisciplinary impact might help track potential ‘Charge type’ breakthrough developments.

Keywords: R&D dynamics; HIV/AIDS drugs development; Bridging researchers; Scientific breakthroughs (search for similar items in EconPapers)
Date: 2014
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
http://link.springer.com/10.1007/s11192-014-1330-7 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:scient:v:101:y:2014:i:1:d:10.1007_s11192-014-1330-7

Ordering information: This journal article can be ordered from
http://www.springer.com/economics/journal/11192

DOI: 10.1007/s11192-014-1330-7

Access Statistics for this article

Scientometrics is currently edited by Wolfgang Glänzel

More articles in Scientometrics from Springer, Akadémiai Kiadó
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().