Evaluating Health Related Quality of Life in Older People at Risk of Osteoporotic Fracture: A Head-to-Head Comparison of the EQ-5D-5L and AQoL-6D

Lei Si, Liudan Tu, Ya Xie, Gang Chen, Mickaël Hiligsmann, Mingcan Yang, Yanli Zhang, Xi Zhang, Yutong Jiang, Qiujing Wei, Jieruo Gu () and Andrew J. Palmer
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Lei Si: UNSW Sydney
Liudan Tu: Third Affiliated Hospital of Sun Yat-Sen University
Ya Xie: Third Affiliated Hospital of Sun Yat-Sen University
Gang Chen: Monash University
Mickaël Hiligsmann: Maastricht University
Mingcan Yang: Third Affiliated Hospital of Sun Yat-Sen University
Yanli Zhang: Third Affiliated Hospital of Sun Yat-Sen University
Xi Zhang: Third Affiliated Hospital of Sun Yat-Sen University
Yutong Jiang: Third Affiliated Hospital of Sun Yat-Sen University
Qiujing Wei: Third Affiliated Hospital of Sun Yat-Sen University
Jieruo Gu: Third Affiliated Hospital of Sun Yat-Sen University
Andrew J. Palmer: University of Tasmania

Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, 2022, vol. 160, issue 2, No 19, 809-824

Abstract: Abstract We aimed to conduct a head-to-head comparison of the five-level version of the EuroQol five-dimensional questionnaire (EQ-5D-5L) and the Assessment of Quality of Life-6D (AQoL-6D) in measuring health-related quality of life (HRQoL) of older people at risk of osteoporotic fracture. Participants (n = 291) were recruited from the Third Affiliated Hospital of Sun Yat-Sen University. Study participants were asked to complete the EQ-5D-5L and the AQoL-6D and the results were converted to health-state utilities (HSUs) using population-specific scoring algorithms. The agreement among HSUs was evaluated using the intraclass correlation coefficient and illustrated using Bland–Altman plots. The minimally important difference (MID) for the EQ-5D and AQoL was set at 0.074 and 0.06. Information on socio-demographic background, socio-economic status and clinical risk factors in FRAX® was collected. Nonparametric statistics were used to explore the known-group validity measured by fracture risk. Mean (median) EQ-5D-5L and AQoL-6D HSUs were 0.73(0.83) and 0.74(0.79) for the study population. The EQ-5D-5L and the AQoL-6D HSUs strongly agreed and the HSU difference reached the MID level in both instruments. While a decreasing trend of AQoL-6D utilities was observed with worsening bone mineral density, EQ-5D-5L HSUs were similar in individuals with normal and osteopenic bone mineral densities. The AQoL-6D was also effective for measuring difference in independent living, relationships, mental health, coping and pain. Both instruments showed good known-group validity. The EQ-5D-5L and AQoL-6D are all valid measures for older people at risk of osteoporotic fracture.

Keywords: Health-related quality-of-life; EQ-5D; Assessment of quality of life; Chinese; Osteoporosis (search for similar items in EconPapers)
Date: 2022
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DOI: 10.1007/s11205-020-02414-8

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