Joint Microbial and Metabolomic Network Estimation with the Censored Gaussian Graphical Model

Jing Ma ()
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Jing Ma: Fred Hutchinson Cancer Research Center

Statistics in Biosciences, 2021, vol. 13, issue 2, No 9, 372 pages

Abstract: Abstract Joint analysis of microbiome and metabolomic data represents an imperative objective as the field moves beyond basic microbiome association studies and turns towards mechanistic and translational investigations. We present a censored Gaussian graphical model framework, where the metabolomic data are treated as continuous and the microbiome data as censored at zero, to identify direct interactions (defined as conditional dependence relationships) between microbial species and metabolites. Simulated examples show that our method metaMint performs favorably compared to the existing ones. metaMint also provides interpretable microbe-metabolite interactions when applied to a bacterial vaginosis data set. R implementation of metaMint is available on GitHub.

Keywords: Data integration; Microbiome; Metabolomics; Censored Gaussian graphical models; Conditional dependence (search for similar items in EconPapers)
Date: 2021
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DOI: 10.1007/s12561-020-09294-z

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