Strategies for Genomic and Proteomic Profiling of Cancers

Gilbert S. Omenn ()
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Gilbert S. Omenn: University of Michigan

Statistics in Biosciences, 2016, vol. 8, issue 1, No 1, 7 pages

Abstract: Abstract Omics-based technology platforms have made new kinds of cancer profiling tests feasible. There are several valuable examples in clinical practice, and many more under development. A concerted, transparent process of discovery with lock-down of candidate assays and classifiers and clear specification of intended clinical use is essential. The Institute of Medicine has now proposed a three-stage scheme of confirming and validating analytical findings, validating performance on clinical specimens, and demonstrating explicit clinical utility for an approvable test (Micheel et al., Evolution of translational omics: lessons learned and path forward, 2012).

Keywords: Cancer proteomics; Biomarker discovery; Bioinformatics; Omics-based clinical assays; Splice isoforms; Her2/neu breast cancer (search for similar items in EconPapers)
Date: 2016
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DOI: 10.1007/s12561-014-9111-7

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