On pooling data summaries in the absence of interactions “response-by-study”

Kepher Henry Makambi
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Kepher Henry Makambi: Howard University Cancer Center

Statistical Methods & Applications, 2002, vol. 11, issue 1, No 8, 127-138

Abstract: Abstract The standard hypothesis testing procedure in meta-analysis (or multi-center clinical trials) in the absence of treatment-by-center interaction relies on approximating the null distribution of the standard test statistic by a standard normal distribution. For relatively small sample sizes, the standard procedure has been shown by various authors to have poor control of the type I error probability, leading to too many liberal decisions. In this article, two test procedures are proposed, which rely on thet—distribution as the reference distribution. A simulation study indicates that the proposed procedures attain significance levels closer to the nominal level compared with the standard procedure.

Keywords: Fixed effects model; Patnaik's approximation; attained significance levels; confidence intervals; probability difference (search for similar items in EconPapers)
Date: 2002
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DOI: 10.1007/BF02511450

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