A randomized two stage allocation for continuous response clinical trials

Rahul Bhattacharya () and Madhumita Shome ()

Statistical Methods & Applications, 2015, vol. 24, issue 3, 373-386

Abstract: A randomized two treatment allocation design, conducted in two stages, is proposed for a class of continuous response trials. Patients are assigned to each treatment in equal numbers in the first stage and p value of a test of equality of treatment effects based on these data is used to determine the assignment probability of second stage patients. Relevant properties of the proposed allocation design are investigated and compared with suitable competitors. Copyright Springer-Verlag Berlin Heidelberg 2015

Keywords: Two stage allocation; Clinical trials; p value (search for similar items in EconPapers)
Date: 2015
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DOI: 10.1007/s10260-014-0267-6

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