How temporal patterns of medication adherence to antidepressants, bisphosphonates and statins are associated with healthcare cost

Kyu Hyung Park, Leonie Tickle and Henry Cutler

Applied Economics, 2024, vol. 56, issue 11, 1283-1308

Abstract: We evaluate benefits of measuring temporal patterns of medication use using group-based trajectory modelling (GBTM) by finding associations between medication adherence (MA) and healthcare costs for which inconsistent results have been reported. We conducted a retrospective cohort study of 9,287, 1,660 and 10,242 users of antidepressants, bisphosphonates and statins, respectively, between 2012 and 2016, who participated in the 45 and Up Study in New South Wales, Australia. Associations between MA and subsequent 1-year healthcare cost components from generalized linear models and two-part models were compared across medications and MA measure types including GBTM and proportion of days covered (PDC). Compared to adherers, antidepressant users with declining adherence showed increased inpatient costs ($643 at p

Date: 2024
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DOI: 10.1080/00036846.2023.2176446

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