Improving estimation efficiency for semi-competing risks data with partially observed terminal event

Menggang Yu

Journal of Nonparametric Statistics, 2016, vol. 28, issue 4, 860-874

Abstract: Semi-competing risks data arise when two types of events, non-terminal and terminal, may be observed. When the terminal event occurs first, it censors the non-terminal event. Otherwise the terminal event is observable after the occurrence of the non-terminal event. In practice, it can be hard to ascertain all terminal event information after the non-terminal event. Yu and Yiannoutsos [(2015), ‘Marginal and Conditional Distribution Estimation from Double-Sampled Semi-Competing Risks Data’, Scandinavian Journal of Statistics, 42, 87–103] considered a setting when the terminal event is ascertained via double sampling from only a subset of patients who experienced the non-terminal event. They discussed estimation for marginal and conditional distributions under this double sampled semi-competing risk data framework. We propose a more efficient estimation method in the same setting by fully utilising the non-terminal event information. The efficiency gain can be substantial as observed in our simulation study.

Date: 2016
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DOI: 10.1080/10485252.2016.1234051

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