Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies

Mulugeta Gebregziabher, Mark A. Eckert, Lois J. Matthews, Abeba A. Teklehaimanot and Judy R. Dubno

Communications in Statistics - Theory and Methods, 2018, vol. 47, issue 22, 5418-5434

Abstract: Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering and nesting. To address limitations in existing methods, we propose a multivariate generalized linear mixed model (mGLMM) and assess its performance. We demonstrate its application using a unique dataset from a cohort study of age-related hearing loss.

Date: 2018
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DOI: 10.1080/03610926.2017.1395045

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