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Conditionally unbiased estimation in the normal setting with unknown variances

David S. Robertson and Ekkehard Glimm

Communications in Statistics - Theory and Methods, 2019, vol. 48, issue 3, 616-627

Abstract: To efficiently and completely correct for selection bias in adaptive two-stage trials, uniformly minimum variance conditionally unbiased estimators (UMVCUEs) have been derived for trial designs with normally distributed data. However, a common assumption is that the variances are known exactly, which is unlikely to be the case in practice. We extend the work of Cohen and Sackrowitz (Statistics & Probability Letters, 8(3):273-278, 1989), who proposed an UMVCUE for the best performing candidate in the normal setting with a common unknown variance. Our extension allows for multiple selected candidates, as well as unequal stage one and two sample sizes.

Date: 2019
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DOI: 10.1080/03610926.2017.1417429

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