A multi-treatment two stage adaptive allocation for survival outcomes

Rahul Bhattacharya and Madhumita Shome

Communications in Statistics - Theory and Methods, 2019, vol. 48, issue 8, 2001-2013

Abstract: A multi-treatment two stage adaptive allocation design is developed for survival responses. Assuming noninformative random censoring, asymptotic p values of relevant tests of equality of treatment effects are used to derive the assignment probability of incoming second stage subjects. Several ethical and inferential criteria of the design are studied, and are compared with those of an existing competitor. Applicability and performance of the proposed design are also illustrated using a data arising from a real clinical trial.

Date: 2019
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DOI: 10.1080/03610926.2018.1440599

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