Estimation of complier causal treatment effects under the additive hazards model with interval-censored data

Yuqing Ma, Peijie Wang, Shuwei Li and Jianguo Sun

Communications in Statistics - Theory and Methods, 2024, vol. 53, issue 10, 3547-3567

Abstract: Estimation of causal treatment effects has attracted a great deal of interest in many areas including social, biological and health science, and for this, instrumental variable (IV) has become a commonly used tool in the presence of unmeasured confounding. In particular, many IV methods have been developed for right-censored time-to-event outcomes. In this paper, we consider a much more complicated situation where one faces interval-censored time-to-event outcomes, which are ubiquitously present in studies with, for example, intermittent follow-up but are challenging to handle in terms of both theory and computation. A sieve maximum likelihood estimation procedure is proposed for estimating complier causal treatment effects under the additive hazards model, and the resulting estimators are shown to be consistent and asymptotically normal. A simulation study is conducted to evaluate the finite sample performance of the proposed approach and suggests that it works well in practice. It is applied to a breast cancer screening study.

Date: 2024
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DOI: 10.1080/03610926.2022.2155791

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