A general strategy for reducing the variability in response-adaptive designs

Mohammed Shahid Abdulla and L. Ramprasath

Communications in Statistics - Theory and Methods, 2025, vol. 54, issue 13, 3871-3881

Abstract: Adaptive designs for clinical trials address the ethical requirement of allocating fewer patients to the inferior treatment as the trial progresses. We present here a generic strategy partly motivated by play-the-winner heuristic for reducing the variability of such designs. It is shown through simulations from a real clinical setting that employing this strategy improves the safety and the performance of some standard response adaptive designs. A closely related alternate strategy amenable to a theoretical analysis is also proposed with the same objective of lower variability.

Date: 2025
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DOI: 10.1080/03610926.2024.2408576

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