Modeling the TB/HIV-1 Co-Infection and the Effects of Its Treatment

Gesham Magombedze, Winston Garira and Eddie Mwenje

Mathematical Population Studies, 2010, vol. 17, issue 1, 12-64

Abstract: Modeling the interaction of Tuberculosis (TB) and AIDS (HIV) drugs in the treatment of the TB/HIV co-infection shows that the treatment of Mtb (Mycobacterium tuberculosis) and AIDS improves. The administration of HIV drugs without TB drugs during co-infection favors the treatment of HIV, but the patient will eventually die of the Mtb opportunistic infection. Reducing the interaction of TB and HIV drugs and increasing the performance (efficiency of inhibition) of Reverse Transcriptase Inhibitors (RTIs) in CD4+ T cells improves the treatment of HIV and leads to the preferential replication of HIV particles in macrophages. The simultaneous administration of TB and HIV drugs is to be recommended for it prevents patients from dying of the Mtb opportunistic infection.

Keywords: AIDS; co-infection; highly active anti-retroviral therapy (HAART); Mycobacterium tuberculosis; TB chemotherapy (search for similar items in EconPapers)
Date: 2010
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DOI: 10.1080/08898480903467241

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