Model based optimization of biochemical systems using multiple objectives: a comparison of several solution strategies

Oscar H. Sendín, Julio Vera, Nestor V. Torres and Julio R. Banga

Mathematical and Computer Modelling of Dynamical Systems, 2006, vol. 12, issue 5, 469-487

Abstract: In this work we consider multi-objective optimization problems arising from the domain of biochemical systems, namely metabolic pathways, with the ethanol production by Saccharomyces cerevisiae as a case study. The goals are to maximize the rate of production of ethanol and simultaneously minimize several internal metabolite concentrations, imposing additional constraints in order to ensure cell viability. As a result, the Pareto-optimal set is obtained for different formulations of the optimization problem. Starting from a detailed, nonlinear, kinetic model of the pathway, several recent solution strategies and other well-known techniques are compared, highlighting the advantages and drawbacks of each one.

Date: 2006
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DOI: 10.1080/13873950600723442

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