Dynamical biocontrol systems: insights through mechanistic modelling

R. M. Javier and J. J. DiStefano

Mathematical and Computer Modelling of Dynamical Systems, 2008, vol. 15, issue 1, 1-16

Abstract: Dynamical biological systems can be modelled mathematically at many levels, from relatively macroscopic, i.e. aggregating many processes or components into subsystem blocks and associated equations characterizing overall behaviour, to microscopic, i.e. focusing on physical mechanisms at the level of individual molecules and associated unit-process equations reflecting such couplings. Here we examine some representative examples within this spectrum of approaches, illustrating the ways in which various investigators handle data-driven modelling problems associated with drug effects--from mostly blood-borne data; switch-like responses in cell signalling subsystems--from molecular biochemistry data; gene network regulation--from pharmacogenomics data; and tumour-suppressor protein regulation mechanisms--also from molecular biochemistry data. Special attention is given to the latter, as modelling of the potential mechanisms involved in this system is an ongoing investigation in our lab. The biosystem model representations described here demonstrate to varying degrees the power of more microscopic methods for discriminating between alternative mechanistic hypotheses of biocontrol system connectivity and dynamics.

Date: 2008
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
http://hdl.handle.net/10.1080/13873950802379340 (text/html)
Access to full text is restricted to subscribers.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:taf:nmcmxx:v:15:y:2008:i:1:p:1-16

Ordering information: This journal article can be ordered from
http://www.tandfonline.com/pricing/journal/NMCM20

DOI: 10.1080/13873950802379340

Access Statistics for this article

Mathematical and Computer Modelling of Dynamical Systems is currently edited by I. Troch

More articles in Mathematical and Computer Modelling of Dynamical Systems from Taylor & Francis Journals
Bibliographic data for series maintained by Chris Longhurst ().