Mathematical modelling of acute virus influenza A infections

John F. Moxnes and Kjell Hausken

Mathematical and Computer Modelling of Dynamical Systems, 2012, vol. 18, issue 5, 521-538

Abstract: This article models the immune system and the virus dynamics of acute influenza infection mathematically. We use the model to study the virus dynamics of some well-known and severe and mild types of viruses. Linkages to well-known models in the literature are illustrated. Simulations are compared with experimental results in vivo by comparing with results from infected ferrets where infection closely resembles those in humans. Good agreement is achieved between the model calculations and the experimental values for influenza A viruses. For the Spanish flu virus H1N1 peak virus load is high and virtually all cells are infected in the nostril. In general, the H1N1 viruses show much more prolonged infections than the H3N2 in the nostril. We suggest that the reason is that unspecific immunity attacks H3N2-budded viruses but not H1N1 viruses.

Date: 2012
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DOI: 10.1080/13873954.2012.669387

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