Photothermal therapy of cancer cells enhanced by glutathione (GSH) modified small-sized gold nanoparticles

Lamyaa F. A. AL-Barram, Selma M. H. AL-Jawad, Ali A. Taha and Natheer Jamal Imran

Journal of Electromagnetic Waves and Applications, 2020, vol. 34, issue 18, 2467-2487

Abstract: Small-sized gold nanoparticles (∼3nm) coated with Glutathione (GSH) ligand have designed as an active agent in photothermal therapy (PTT). GSH is pH-sensitive surface that have a fast response property to the variation in pH conditions, especially between normal (∼7.4) and cancer cell (6–6.5), that help the evaluation of the target and toxic effect of the cancer rather than normal cells. Results revealed considerable toxic effects of GSH-AuNPs accumulation in cancer cells for both green and NIR laser irradiation. The GSH-AuNPs represent promising agents for developing the safety issues of photothermal cancer treatment by; the selective targeting of the cancer rather than normal cells, reducing the NPs toxicity by their size overlapping with the renal clearance barrier of kidney filtration (~5.5 nm), and promoting the photothermal performance in the NIR region, in which light penetration into deep cancer regions are more interested.

Date: 2020
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DOI: 10.1080/09205071.2020.1822759

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