Human health problems associated with molecular impact induced by chemical pollutants as endocrine disruptors

Verginica Schröder, Manuela Rossemary Apetroaei, Irina Mihaela Iancu, Gabriela Mitea, Valeriu Iancu, Adina Honcea, Sirma Tomos, Laura Adriana Bucur and Cristina-Luiza Erimia
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Verginica Schröder: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania
Manuela Rossemary Apetroaei: Faculty of Navigation and Naval Management, Mircea cel Bătrân Naval Academy, Constanța, 900218, Romania
Irina Mihaela Iancu: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania
Gabriela Mitea: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania
Valeriu Iancu: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania
Adina Honcea: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania, Laboratory of Microbiology and Immunology, CF Hospital, Constanta, Romania
Sirma Tomos: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania, Laboratory of Microbiology and Immunology, CF Hospital, Constanta, Romania
Laura Adriana Bucur: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania
Cristina-Luiza Erimia: Faculty of Pharmacy, “Ovidius” University of Constanta, 900470, Romania

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2023, vol. 7, issue 1, 103-110

Abstract: Chemicals reaching the human body can affect the endocrine system by inducing hormone agonist or antagonist effects or by altering hormone synthesis reactions. Exposure to the body can be either through ingestion or inhalation (food, drinking water, air) or through direct contact with certain substances in general use (industry, cosmetics, etc.). The human health problems identified and associated with endocrine disrupters are mainly related to dysfunctions of the reproductive system or lipid metabolism. Also, exacerbating exposure can lead to irreversible changes at the molecular level and carcinogenesis. Worryingly, it can have long-term consequences through changes in genetic and epigenetic regulatory pathways. Legislation at the European level seeks to harmonize ways of protecting human health through regulations related to basic research, environmental risk assessment, promotion of sustainable development, protection of vulnerable ecosystems, and continuous information and updating of risk data.

Date: 2023
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