Coagulopathy parameters in symptomatic and asymptomatic Pregnant Women with COVID-19

Ana-Maria Pelin, Nicoleta Maricica Maftei, Costinela Georgescu, Ștefan Roşca, Ramona Oana Roşca, Ioana Pelin and Cristina Ștefanescu
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Ana-Maria Pelin: Pharmaceutical Science Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galati, Romania
Nicoleta Maricica Maftei: Pharmaceutical Science Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galati, Romania & Medical Laboratory Department, "Sfântul Ioan" Children's Emergency Hospital Galați, Romania
Costinela Georgescu: Pharmaceutical Science Department, Faculty of Medicine and Pharmacy, “Dunărea de 11Jos” University, Galati, Romania; & Departament of Public Health, Clinical Hospital of obstetrics and gynecology “Buna Vestire“, Galati, Romania
Ștefan Roşca: Medical Department, Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 80010, Galati, Romania
Ramona Oana Roşca: Pharmaceutical Science Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galati, Romania
Ioana Pelin: Student of the Faculty of Medicine - Carol Davila University of Medicine and Pharmacy Bucharest, Romania
Cristina Ștefanescu: Dental Medicine Department, Faculty of Medicine and Pharmacy, “Dunărea de Jos” University, Galati, Romania

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2024, vol. 8, 48-63

Abstract: Abstract: Purpose: The purpose of the study was to determine if the physiological hypercoagulability during pregnancy is compounded by SARS-CoV-2 infection-induced coagulability. Patients and methods: We retrospectively analysed (October 2020 and August 2021) modifications of the coagulation parameters recommended by the ISTH (International Society on Thrombosis and Haemostasis) (fibrinogen, APTT, PT, INR, D-dimers complete blood count) in 96 pregnant women infected with SARS-CoV-2. Results: Our results indicated that none patients had severe evolution of the SARS-CoV-2 infection and did not require transfer to the ICU. We also monitored the variation of such parameters, depending on subsequent SARS-CoV-2 PCR screening tests. We established that the laboratory parameters used to assess the coagulability are directly correlated with positive SARS-CoV-2 tests, and pregnancy represents a condition that is likely to increase the risk of embolisms in pregnant patients infected with SARS-CoV-2, compared with the general population. No cases of confirmed SARS-CoV-2 infection were observed in the neonates. Conclusion: Knowledge of laboratory modifications with prognostic utility in relation to coagulation may be extremely valuable in the management of pregnant women with COVID-19. A better understanding of coagulopathy caused by COVID-19 would also be helpful to guide treatment recommendations for pregnant women. Pregnancy may also be an additional risk factor for coagulopathy in women infected with SARS-CoV-2 in both symptomatic and asymptomatic positive pregnant women.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:tec:bioche:ojs:10893

DOI: 10.47577/biochemmed.v8i.10893

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