Retrosynthetic Analysis of Centratherolide A

Nathan S Lee
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Nathan S Lee: Philips Academy Andover, 7 Chapel Ave, Andover, MA 01810, USA

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2025, vol. 13, 227-236

Abstract: Centratherolide A is small and permeable, yet it can cause selective irreversible reactions to proteins, including topoisomerase-3β(TOP3B), the only dual RNA and DNA topoisomerase found in humans. Centratherolide A is mainly cytotoxic because of its α-methylene-γ-lactone ring, a potent Michael Acceptor present in their family of Furanoheliangolides and sesquiterpene lactones. Through the common atom analysis, oxidation level analysis, Michael Addition, and common carbon relationships, Centratherolide A was able to be broken down into 7 parts. Trisecting the main chain seems more plausible than bisecting. Further understanding of different R groups and variations propose a possibility of cytotoxicity against other diseases and cancers.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:tec:bioche:ojs:13325

DOI: 10.47577/biochemmed.v13i.13325

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