The Role of K+, Ca2+ channels, Some Endothelium Hyperpolarizing Factors in Taurine Induced Vasorelaxation in Rats Aorta

Abdulsatar A. Haji () and Omar A.M. Al-Habib ()
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Abdulsatar A. Haji: Dept. of Biology, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq
Omar A.M. Al-Habib: College of Science, Nawroz University, Duhok, Kurdistan Region, Iraq

Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, 2021, vol. 2, issue 1, 101-109

Abstract: The current study included the relaxant effect of taurine on rat’s aortic rings and the mechanism behind this relaxation. Taurine produced a potent spasmolytic effect on aortic rings at concentrations from zero to 80 mM. The results of K+ channel subtypes using specific blockers indicated that the Kv channel has a considerable role in taurine-induced relaxation, while KATP has a limited role, Exposure of aortic rings to combinations of two K+ blockers showed that KCa, Kv, and KIR play important role in taurine mediated relaxation. The endothelium-derived hyperpolarizing factors used showed responses to a variable extent in taurine mediated relaxation; since NO and cGMP played a major role whereas PGS played a minor role in taurine mediated relaxation. Finally, the results also indicated that taurine-mediated relaxation is endothelium-dependent.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:tec:bioche:v:2:y:2021:i:1:p:101-109

DOI: 10.47577/biochemmed.v2i1.3234

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