Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy

Jie Lv, Jin-feng Cao, Yan Cai, Yu Zhou, Quan Long, Wei Yao and Shi-xiong Xu

Journal of Applied Mathematics, 2011, vol. 2011, issue 1

Abstract: To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://doi.org/10.1155/2011/190371

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wly:jnljam:v:2011:y:2011:i:1:n:190371

Access Statistics for this article

More articles in Journal of Applied Mathematics from John Wiley & Sons
Bibliographic data for series maintained by Wiley Content Delivery ().