Complications of peripherally inserted central catheters in advanced cancer patients undergoing combined radiotherapy and chemotherapy

Jun Xie, Linjie Xu, Xiaomin Xu and Yunjuan Huang

Journal of Clinical Nursing, 2017, vol. 26, issue 23-24, 4726-4733

Abstract: Aims and objectives To identify whether patients with advanced cancers were at high risk of peripherall"y inserted central catheter‐related complications when treated with concurrent chemo‐radiotherapy. Background Peripherally inserted central catheters are widely used in chemotherapy. However, catheter usage may elevate the risks of infections and thrombosis. It is important to identify the patients with high risk of peripherally inserted central catheter‐related complications. To date, little is known about peripherally inserted central catheter‐related complications in patients with advanced cancers and receiving concurrent chemo‐radiotherapy. Design Five hundred and sixty‐nine cancer patients with advanced cancers and treated by chemo‐radiotherapy were analysed in the study. The incidences of peripherally inserted central catheter‐related complications were investigated. Methods Univariable and multivariable logistic regression analyses were employed for identification of risk factors. Results Eighty‐six (15.1%) patients exhibited peripherally inserted central catheter‐related infectious complications, of which 6.3% were local infection, 3.9% were catheter‐related bloodstream infection and 4.9% were exit‐site infection. Sixty‐five (11.4%) developed symptomatic peripherally inserted central catheter‐related thrombosis, and 52 (9.1%) were suffering from phlebitis. The overall complication rate was 53.1%. The univariable logistic regression and multivariate analysis showed that comorbidity (OR 1.51, p = .0148) and body mass index (OR 1.46, p = .0157), and duration of radio‐chemotherapy (OR 1.4733, p = .0049) were significantly associated with peripherally inserted central catheter‐related complications. Patients with peripherally inserted central catheter‐related complications showed lower 5‐year survival rate than those without peripherally inserted central catheter‐related complications. Conclusions Identification of risk factors for peripherally inserted central catheter‐related complications in patients with advanced cancer before catheter usage may play an important role in improvement of the prognosis. Relevance to clinical practice Doctors need to be aware of the risk of peripherally inserted central catheter‐related complications in patients with advanced cancers.

Date: 2017
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://doi.org/10.1111/jocn.13825

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:wly:jocnur:v:26:y:2017:i:23-24:p:4726-4733

Access Statistics for this article

More articles in Journal of Clinical Nursing from John Wiley & Sons
Bibliographic data for series maintained by Wiley Content Delivery ().