EFFECTS OF SELECTIVE ADVANTAGE OF HbS OVER HbA IN THE TRANSMISSION DYNAMICS OF SICKLE CELL ANAEMIA

Jean M. Tchuenche ()
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Jean M. Tchuenche: Department of Mathematical Sciences, University of Agriculture, PMB 2240, Abeokuta, Nigeria

Advances in Complex Systems (ACS), 2005, vol. 08, issue 01, 1-5

Abstract: Despite rising concern over the biology of Sickle Cell Anaemia (SCA), no general modeling approach has considered the effects of the selective advantage of Haemoglobin S (HbS) over Haemoglobin (HbA). This paper develops a theoretical framework and demonstrates mathematically that mating between the three different genotypic groups, namely: normal AA, carriers AS and sicklers SS, does not yield equal probabilities of having neonates of these classes.

Keywords: Selective advantage; transmission dynamics; renewal equation; Sickle Cell Anaemia (search for similar items in EconPapers)
Date: 2005
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DOI: 10.1142/S0219525905000300

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