MULTIFRACTAL CHARACTERISTICS OF THE MITOCHONDRIAL BK CHANNEL ACTIVITY IN THE PRESENCE OF THE CHANNEL-ACTIVATING FLAVONOIDS

Paulina Trybek, Å Ukasz Machura, Piotr Bednarczyk, Urszula Cojg, PODLEÅšNY Patrycja, Kamila Szumaå A and Agata Wawrzkiewicz-Jaå Owiecka
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Paulina Trybek: Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzow, Poland
ŠUkasz Machura: Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzow, Poland
Piotr Bednarczyk: Department of Physics and Biophysics, Institute of Biology, Warsaw University of Life Sciences — SGGW, Warszawa 02-787, Poland
Urszula Cojg: Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice 44-100, Poland
PODLEÅšNY Patrycja: Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice 44-100, Poland
Kamila Szumaå A: Faculty of Biomedical Engineering, Silesian University of Technology, Gliwice 44-100, Poland
Agata Wawrzkiewicz-Jaå Owiecka: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, Gliwice 44-100, Poland

FRACTALS (fractals), 2024, vol. 32, issue 05, 1-19

Abstract: Over the years, the (multi)fractal nature of signals describing the activity of ion channels has been observed both at the level of single-channel currents and the temporal scaling of the corresponding sojourns in conducting and non-conducting states. The recognized nonlinear and self-similar properties were interpreted regarding the underlying channel gating machinery. Nevertheless, the literature lacks in (multi)fractal description of the biochemical stimulation of ion channels. Therefore, in this work, we provide a multifractal description of the effects exerted by two different flavonoids — naringenin (Nar) and quercetin (Que) — being the regulators of the large-conductance voltage- and Ca2+-activated K+ channels from the inner mitochondrial membrane (mitoBK). Toward this aim, the focus-based multifractal detrended fluctuation analysis (MFDFA) was applied to the patch-clamp data obtained in the presence of Nar and Que in micromolar concentrations and the corresponding controls. Our results show that mitoBK channel activity has well-pronounced multifractal characteristics and long-range memory (measured by the generalized Hurst exponent) under biochemical stimulation by Nar and Que and in the absence of these substances. The spectral properties significantly change after the randomization of the analyzed series. Therefore, multifractality is an inherent feature of the mitoBK channel currents, which stems from their statistical distribution and temporal organization. Both flavonoids have similar structures and exert channel-activating effects, but they differently affect the parameters of the multifractal spectra of the corresponding patch-clamp signals. Coordination of Que leads to more prominent changes in signal complexity than Nar at membrane hyper- and depolarization. It suggests that this flavonoid has a stronger impact on the conformational dynamics of the mitoBK channels in comparison with naringenin.

Keywords: mitoBK Channels; Patch-Clamp; MFDFA; Multifractal Characteristics; Hurst Exponent; Quercetin; Naringenin; Flavonoids (search for similar items in EconPapers)
Date: 2024
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DOI: 10.1142/S0218348X24501019

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