POLYMER MICROSPHERES WITH PERMANENT ANTIBACTERIAL SURFACE FROM SURFACE-INITIATED ATOM TRANSFER RADICAL POLYMERIZATION OF 4-VINYLPYRIDINE AND QUATERNIZATION

Zhenping Cheng, Xiulin Zhu, Z. L. Shi, K. G. Neoh and E. T. Kang ()
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Zhenping Cheng: School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215006, P. R. China
Xiulin Zhu: School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215006, P. R. China
Z. L. Shi: Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore
K. G. Neoh: Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore
E. T. Kang: Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore

Surface Review and Letters (SRL), 2006, vol. 13, issue 02n03, 313-318

Abstract: Crosslinked poly(4-vinylbenzyl chloride) (PVBC) microspheres of about 550 μm in diameter were first synthesized by suspension copolymerization of 4-vinylbenzyl chloride (VBC) in the presence of a crosslinking agent, ethylene glycol dimethacrylate (EGDMA). Subsequent surface-initiated atom transfer radical polymerization (ATRP) of 4-vinylpyridine (4VP), using the VBC units of PVBC on the microsphere surface as the macroinitiators, produced well-defined (nearly monodisperse) and covalently tethered poly(4-vinylpyridine) (P4VP) brushes. Quaternization of the tertiary amine groups of the P4VP brushes with hexyl bromide gave rise to a high concentration of quaternary ammonium salt (QAS) on the microsphere surfaces. The chemical composition of the microsphere surfaces at various stages of surface modification was characterized by X-ray photoelectron spectroscopy (XPS). The bactericidal effect of the QAS-functionalized microspheres onEscherichia coli (E. coli)was demonstrated. No significant loss in the surface bactericidal activity of the microsphere was observed during repeated applications.

Keywords: Bactericidal microsphere; quaternization; ATRP; Poly(4-vinylpyridine); alkyl halides (search for similar items in EconPapers)
Date: 2006
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DOI: 10.1142/S0218625X06008220

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