ELECTROCHEMICAL BEHAVIORS OF MATRINE AT L-CYSTEINE-MODIFIED ELECTRODES

Yuqing Miao (), Jianrong Chen and Xiaohua Wu
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Yuqing Miao: Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Lab of Bioanalysis and Biosensor, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua 321004, China
Jianrong Chen: Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Lab of Bioanalysis and Biosensor, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua 321004, China
Xiaohua Wu: Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Lab of Bioanalysis and Biosensor, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua 321004, China

Surface Review and Letters (SRL), 2008, vol. 15, issue 05, 537-543

Abstract: Matrine is an important natural occurring component insophoraroots. It has a wide range of pharmacological actions. In this work, electrochemical investigation of matrine and its interaction with L-cysteine (L-Cys) is reported. Via the electrochemical approach, we have proved that the distribution coefficients of protonated and deprotonated matrine affect its electrochemical response onAuor L-Cys modifiedAuelectrodes. The study by ultraviolet spectroscopy also finds that the molecular interaction between matrine and L-Cys changes with the distribution coefficients of protonated and deprotonated matrine at different pH value. Compared with the response of matrine on the bare gold electrode, theL-Cys/Auself-assembled monolayers modified electrodes exhibit obviously higher current response toward matrine oxidation. The oxidation current of matrine at L-Cys assembled electrode has a good linear relation in the range of 0.2–5 mM, with the correlation coefficient of 0.989 by cyclic voltammagrams. Electrochemical combined with spectroscopic techniques would provide relatively easy way to better understand the underlying mechanism of matrine/L-Cys interaction and will be helpful for the development of electroanalytical techniques for the determination of matrine.

Keywords: Matrine; self-assembled monolayers; chemically modified electrodes; L-cysteine (search for similar items in EconPapers)
Date: 2008
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DOI: 10.1142/S0218625X08011895

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