EXPERIMENTAL INVESTIGATIONS ON THE SURFACE-DRIVEN CAPILLARY FLOW OF AQUEOUS MICROPARTICLE SUSPENSIONS IN THE MICROFLUIDIC LABORATORY-ON-A-CHIP SYSTEMS

Subhadeep Mukhopadhyay
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Subhadeep Mukhopadhyay: Department of Electronics and Computer Engineering, National Institute of Technology, Arunachal Pradesh, India2Ministry of Human Resource Development (Government of India), Yupia, Papum Pare-791112, Arunachal Pradesh, India

Surface Review and Letters (SRL), 2017, vol. 24, issue 08, 1-28

Abstract: In this work, total 1592 individual leakage-free polymethylmethacrylate (PMMA) microfluidic devices as laboratory-on-a-chip systems are fabricated by maskless lithography, hot embossing lithography, and direct bonding technique. Total 1094 individual Audio Video Interleave Files as experimental outputs related to the surface-driven capillary flow have been recorded and analyzed. The influence of effective viscosity, effect of surface wettability, effect of channel aspect ratio, and effect of centrifugal force on the surface-driven microfluidic flow of aqueous microparticle suspensions have been successfully and individually investigated in these laboratory-on-a-chip systems. Also, 5 micron polystyrene particles have been separated from the aqueous microparticle suspensions in the microfluidic lab-on-a-chip systems of modified design with 98% separation efficiency, and 10 micron polystyrene particles have been separated with 100% separation efficiency. About the novelty of this work, the experimental investigations have been performed on the surface-driven microfluidic flow of aqueous microparticle suspensions with the investigations on the separation time in particle-size based separation mechanism to control these suspensions in the microfluidic lab-on-a-chip systems. This research work contains a total of 10,112 individual experimental outputs obtained using total 30 individual instruments by author’s own hands-on completely during more than three years continuously. Author has performed the experimental investigations on both the fluid statics and fluid dynamics to develop an automated fluid machine.

Keywords: Capillary flow; lab-on-a-chip; separation; human whole blood (search for similar items in EconPapers)
Date: 2017
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DOI: 10.1142/S0218625X17501074

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