BIOCOMPATIBILITY STUDY OF α-Fe2O3 NANOPARTICLES PREPARED BY HYDROTHERMAL METHOD

Sadeq H. Lafta, Ali Abdulrahman Taha, Muhammad M. Farhan and Shaima Y. Abdulfattah
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Sadeq H. Lafta: Applied Science Department, University of Technology, Iraq
Ali Abdulrahman Taha: Applied Science Department, University of Technology, Iraq
Muhammad M. Farhan: #x2020;Biotechnology Research Center, Al-Nahrain University, Iraq
Shaima Y. Abdulfattah: #x2020;Biotechnology Research Center, Al-Nahrain University, Iraq

Surface Review and Letters (SRL), 2019, vol. 26, issue 09, 1-8

Abstract: Nanoparticles of alpha ferric oxide (α-Fe2O3) were prepared by the hydrothermal method. Structural properties of α-Fe2O3 were determined by XRD, SEM and AFM measurements. The particles had a good matching with standard pattern. Average particle size was about 90nm and the distribution extended from about 20nm to 120nm. Biocompatibility study of ferric oxide nanoparticles against bacteria, parasites, tumor cell line and normal cells was determined. No antibacterial activity was observed for the concentration, of ferric oxide nanoparticles in distilled water, up to 1.5mg/ml vs. E. coli and S. aureus. Moreover, MTT assay was used to determine the cytotoxicity against parasites and cells. Intermediate cytotoxicity (53.30%) of 1.5mg/ml of prepared nanoparticles was noted against L. tropica, while weak cytotoxicity of 5.20% was observed against L. donovani at the same concentration of ferric oxide nanoparticles. On the other hand, the prepared nanoparticles revealed low cytotoxicity (47.28%) against SR tumor cell line, while no cytotoxicity was shown against lymphocytes, as a model of normal cells.

Keywords: α-Fe2O3; biocompatibility; cytotoxicity; cancer; parasites; bacteria (search for similar items in EconPapers)
Date: 2019
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DOI: 10.1142/S0218625X19500586

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