ANTIBACTERIAL ACTIVITY OF BENZOYL AND HALOBENZOYL THIOUREA BEARING α- AND β-ALANINE

Maizatul Akma Ibrahim (), Atiyah Husin, Nurziana Ngah and Nor Hafizah Zakaria
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Maizatul Akma Ibrahim: Department of Plant Science, Kulliyyah of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang.
Atiyah Husin: Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang.
Nurziana Ngah: Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang
Nor Hafizah Zakaria: Department of Plant Science, Kulliyyah of Science, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang.

Journal Clean WAS (JCleanWAS), 2021, vol. 5, issue 1, 35-38

Abstract: Antibacterial activity of synthetically synthesized benzoyl thiourea and halobenzoyl thiourea bearing α-alanine and β-alanine compounds were investigated against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Esherichia coli). The study of antibacterial activity of the compounds was conducted by using the disc diffusion method and minimal inhibitory concentration (MIC) as well as minimal bactericidal concentration (MBC). The results indicate that 4-fluorobenzoylthiourea α-alanine, benzoylthiourea α-alanine, 4-fluorobenzoylthiourea β-alanine, 4-chlorobenzoylthiourea β-alanine, 4-bromobenzoylthiourea β-alanine, and benzoylthiourea β-alanine possess weak to strong antibacterial activity on all of tested bacteria. The strongest antibacterial activity was found in the 4-fluorobenzoylthiourea α-alanine, whereas the weakest antibacterial activity was exhibited in 4-fluorobenzoylthiourea β-alanine. S. aureus was found the most susceptible toward these thiourea derivatives, indicating bactericidal activity against the bacteria.

Keywords: benzoyl thiourea; halobenzoyl thiourea; antibacterial; disc diffusion test; minimum inhibition concentration. (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:zib:jclnws:v:5:y:2021:i:1:p:35-38

DOI: 10.26480/jcleanwas.01.2021.35.38

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