The Investigation Of Cytotoxic Effect Of Cinnamomum Zeylanicum Extracts On Human Breast Cancer Cell Line (Mcf-7)

Widya Abd Wahab and Ainatun Natrah Adzmi
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Widya Abd Wahab: Dept of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, Kuantan Campus, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang
Ainatun Natrah Adzmi: Centre for Teaching and Learning (CTL), Level 2, Kulliyyah of Education, International Islamic University Malaysia,53100 Jalan Gombak, Kuala Lumpur

Science Heritage Journal (GWS), 2017, vol. 1, issue 2, 23-28

Abstract: Cinnamon is one of the oldest herbal medicine that has been historically known to possess has anticancer property. In this study, the cytotoxicity of the cinnamon extracts towards human breast cancer cell line (MCF-7) was investigated. Cinnamomum zeylanicum was extracted using Soxhlet and water extraction methods, producing 7.06% and 2.54% of yield respectively. The extracts were analysed using Gas Chromatography/ Mass Spectrometry (GCMS) and it was found that cinnamaldehyde is the major constituents which contribute more than 70% of the major constituents. The cytotoxicity of C. zeylanicum extract against MCF-7 was determined through colorimetric MTT assay at 24 and 48 hours of incubation periods. The IC50 values of Soxhlet extract were 58 µg/ml and 140 µg/ml while the IC50 values of water extract were 9 mg/ml and 4.8 mg/ml, at 24 and 48 hours treatment respectively. In conclusion, C. zeylanicum extracts has been confirmed to have cytotoxic effect towards MCF-7 cell line in different concentrations at two different incubation periods.

Keywords: Cinnamomum zeylanicum; Soxhlet extract; water extract; cytotoxicity; GCMS; MTT assay; MCF-7; IC50 (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:zib:zbngws:v:1:y:2017:i:2:p:23-28

DOI: 10.26480/gws.02.2017.23.28

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