BRIDELIA FERRUGINEA BARK: PHYTOCHEMICAL ANALYSIS AND BIOACTIVITY ASSESSMENT FOR POTENTIAL THERAPEUTIC APPLICATIONS

Olugbenga David Oloruntola (), Simeon Olugbenga Ayodele, Ojurereoluwa Adebimpe Ayodele, Emmanuel Kehinde Asaniyan, Olufemi Emmanuel Adeniji and Fehintoluwa Stellamaris Oladebeye
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Olugbenga David Oloruntola: Department of Animal Science, Adekunle Ajasin University, Akungba Akoko, Nigeria
Simeon Olugbenga Ayodele: Department of Agricultural Technology, Federal Polytechnic, Ado Ekiti, Nigeria
Ojurereoluwa Adebimpe Ayodele: Department of Animal Science, Adekunle Ajasin University, Akungba Akoko, Nigeria
Emmanuel Kehinde Asaniyan: Department of Animal Production and Health, Olusegun Agagu University of Science and Technology, Okiti Pupa, Nigeria
Olufemi Emmanuel Adeniji: Department of Animal Science, Adekunle Ajasin University, Akungba Akoko, Nigeria
Fehintoluwa Stellamaris Oladebeye: Department of Animal Science, Adekunle Ajasin University, Akungba Akoko, Nigeria

Science Heritage Journal (GWS), 2024, vol. 8, issue 2, 88-93

Abstract: Bridelia ferruguinea bark is investigated for its phytochemical composition and bioactivity to explore its therapeutic potential. The phytochemical analysis reveals significant quantities of alkaloids (62.95 mg/g), saponins (64.31 mg/g), flavonoids (100.19 mg/g), tannins (78.08 mg/g), and phenols (253.62 mg/g). The nitrogen-free extract dominates at 53.23%, followed by crude fiber at 24.44%. Additionally, the moisture, crude protein, crude fat, and ash content in Bridelia ferruguinea bark powder are reported at 7.63%, 2.15%, 8.72%, and 3.83%, respectively. Assessment of bioactivity indicates a lipid inhibition percentage of 23.88% and a vitamin C content of 55.97%. Moreover, the bark exhibits Fe chelation (13.44%) and DPPH radical scavenging activity (83.54%). Furthermore, it demonstrates inhibition of albumin denaturation (62.71%) and antiproteinase activity (69.534%). Importantly, it shows promising α-amylase inhibition (37.60%) and α-glucosidase inhibition (58.07%). These diverse bioactivities suggest potential applications in pharmaceuticals and nutraceuticals, warranting further studies for formulation development targeting both human and animal health. Bridelia ferruguinea bark emerges as a valuable natural resource with multifaceted therapeutic prospects, inviting extensive exploration for practical utilization.

Keywords: Bridelia ferruguinea; Phytochemical analysis; Bioactivity assessment; Therapeutic potential; Pharmaceutical and nutraceutical applications. (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:zib:zbngws:v:8:y:2024:i:2:p:88-93

DOI: 10.26480/gws.02.2024.88.93

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