Pharmacokin etic Study Of Clarithromycin In Human Female Of Pakistani Population

Atifa Mushtaq (), Tanweer Khaliq, Hafiz Alam Sher, Asia Farid, Anila Kanwal and Maliha Sarfraz
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Atifa Mushtaq: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad Pakistan
Tanweer Khaliq: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad Pakistan
Hafiz Alam Sher: Primary and Secondary Health Care Department, Lahore, Pakistan
Asia Farid: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad Pakistan
Anila Kanwal: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad Pakistan
Maliha Sarfraz: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad Pakistan

Matrix Science Pharma (MSP), 2017, vol. 1, issue 2, 13-16

Abstract: The study was designed to assess the various pharmacokinetic parameters of a commercially available clarithromycin Tablet (Klaricid® 250 mg Abbot, Pakistan) in plasma sample of healthy adult female volunteers by applying a rapid, sensitive and accurate HPLC-UV analytical method. The human plasma samples were evaluated by using an isocratic High-Performance Liquid Chromatography (HPLC) system of Sykam consisted of a pump with a column C18 column (250×4.6mn, 5µm) UV-detector. The mobile phase comprises of potassium dihydrogen phosphate (50 mM, pH 6.8, contained 0.7% triethylamine), methanol and acetonitrile (30:25:45, v/v/v) was delivered with injection volume of 20µL at flow rate of 1 mL/min. The detection was performed at λmax 275 nm. By applying this method, important pharmacokinetic parameters Cmax, Tmax, Area under curve (AUC), half-life (t1/2), Volume of distribution (Vd) and Clearance (Cl) were measured. The parameters of pharmacokinetics of clarithromycin were calculated by software (APO) pharmacological analysis. Maximum plasma concentrations Cmax 2.78 ±0.33 µg/ml, time to reach maximum co ncentration tmax 2.82 ± 0.11 h and Area under curve AUC was 20.14h.µg/ml. The mean ± SD values obtained for the pharmacokinetic parameters showed a significant difference in pharmacokinetic parameters observed in previous literature which emphasizes the need for dose adjustment of clarithromycin in Pakistani population.

Keywords: Pharmacokinetics; Clarithromycin; HPLC; Plasma (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:zib:zbnmsp:v:1:y:2017:i:2:p:13-16

DOI: 10.26480/msp.02.2017.13.16

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