Gastroprotective Effe ct Of Avena Sativa (Oat) Seed Grains Against Gastric Ulcer Induced By Indomethacin In Healthy Adult Male Albino Rabbits

Anila Kanwal (), Bilal Aslam, Atifa Mushtaq, Hira Anwar and Hafiz Mahboob Ahmed
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Anila Kanwal: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Bilal Aslam: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Atifa Mushtaq: National Institute of Health, Islamabad, Pakistan
Hira Anwar: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Hafiz Mahboob Ahmed: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan

Matrix Science Pharma (MSP), 2018, vol. 2, issue 1, 14-18

Abstract: Avena sativa which is commonly known as oat has beneficial effects against various diseases especially cancer, bowel syndrome, diabetes, cardiovascular disease and obesity. Gastro protective effect of seed grains of Avena sativa in indomethacin induced ulcer in healthy male adult albino rabbits were evaluated in present study. A total of thirty-six rabbits were divided into six equal groups. Group 1 would be served as control group on routine diet. Indomethacin (indocin) 20 mg/kg was given to 2nd group to induce ulcer, 3rd group was served by synthetic antiulcer drug Zantac (ranitidine) at the dose of 10 mg/kg orally while group 4, 5 and 6 were given three different doses of Avena sativa seed powders 250 mg/kg, 500 mg/kg and 750 mg/kg respectively for 14 days. At the end of experiment rabbits were sacrificed to collect gastric contents for the estimation of total acid output. The blood sample was collected at 0 and 14 days. Antiulcer activity of this plant was analyzed by measuring different parameters like pH, gastric volume, acid output and ulcer index. Result showed that Avena sativa at dose of 750 mg/kg reduced the values of total oxidant status (TOS), malondialdehyde and increased the total antioxidant capacity and catalase activity and these results were compared with standard drug. From these results it was concluded that Avena sativa has strongest antioxidant potential.

Keywords: Avena sativa; avenanthramides; Gastroprotective; antioxidant; Indomethacin; COX- inhibitors; ranitidine; gastric ulcer. (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:zib:zbnmsp:v:2:y:2018:i:1:p:14-18

DOI: 10.26480/msp.01.2018.14.18

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