Renal Clearance And Urinary Excretion Of Moxifloxacin In Healthy Male Volunteers

Asia Farid (), Tanweer Khaliq, Hafiz Alam Sher, Atifa Mushtaq and Abdullah Abid
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Asia Farid: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Tanweer Khaliq: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Hafiz Alam Sher: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Atifa Mushtaq: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan
Abdullah Abid: Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad, Pakistan

Matrix Science Pharma (MSP), 2018, vol. 2, issue 1, 19-22

Abstract: Moxifloxacin is a 4th generation fluoroquinolone. Study was planned on renal clearance and urinary excretion of moxifloxacin on healthy male volunteers by applying sensitive, rapid and accurate HPLC-UC analytical method. For this study 8 healthy male subjects similar in all physical conditions were selected. Moxifloxacin (Avelox® 400 mg) was administered orally under fasting conditions. First sample of urine and blood was collected before administration of moxifloxacin and other samples of blood were taken at 0.5, 1.5, 2.5, 3.5 hr and urine samples were withdrawn at 1, 2, 3, 4, 6, 8, 10, 12, 24, 36 and 48 hr. The pH of the samples was measured by pH meter. Blood and urine samples were analyzed with HPLC for drug determination. Endogenous creatinine was measured by reagent kit method. The plasma concentration of endogenous creatinine and drug were 12.61 ± 0.85 µg/mL and 1.678 ± 0.062 µg/mL. The renal clearance of endogenous creatinine ranges from 1.17 to 3.18 ml/min/kg with an average ± SE value of 2.67 ± 0.24 mL/min/Kg. Renal clearance of moxifloxacin was 0.476 ± 0.04 mL/min/Kg ranged between 0.27 – 0.609 mL/min/Kg. Urinary excretion of moxifloxacin calculated as cumulative percent dose excreted 20.48 ± 0.88. A positive relationship was found between diuresis and renal clearance of drug indicated that besides glomerular filtration passive diffusion is also involved at kidney tubular level.

Keywords: Moxifloxacin; fluoroquinolone; Blood; Endogenous creatinine; glomerular filtration; kidney tubular (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:zib:zbnmsp:v:2:y:2018:i:1:p:19-22

DOI: 10.26480/msp.01.2018.19.22

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