In-Silico Studies of MTNB, TM14A, LEG2, S10A3 and ITC4S Proteins Involved in Lung Cancer

Mini Fernandez and Sarayu Anvsl

Chapter 8 in Convergence of Technology & Biology ─ Transforming Life Sciences, 2025, pp 66-77 from Shanlax Publications

Abstract: Lung cancer has the highest mortality rates among both men and women and is the leading cause of cancer-related deaths worldwide. Research has shown that five proteins—MTNB, TM14A, LEG2, S10A3, and LTC4S—can accelerate the development of lung cancer. These proteins' target sequences, template sequences, and alignments were obtained from UniProtKB, PDB-RCSB, and ClustalOmega. Protein modeling and validation were performed using SWISS-MODEL and the SAVES v6.0 and ProSA tools. Surface pockets were identified using CASTpFold. Each protein was then docked with three selected ligands—sorafenib, distamycin, and sunitinib—using Vina in "PyRx." AutoDock Vina facilitated the separation of ligand conformations. Finally, BIOVIA Discovery Studio was used to visualize the interactions between the proteins and the drugs. Understanding these interactions highlights the potential of these medications as targeted therapies that could reduce tumor growth and improve patient outcomes.

Date: 2025
ISBN: 978-93-6163-763-6
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