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Null effects in trials – a worked example of a maltreatment prevention trial

Michael Robling and Rebecca Cannings-John

Chapter 14 in Experimental Methods and Children's Social Care, 2025, pp 167-188 from Edward Elgar Publishing

Abstract: Abstract: Null effects in trials occur when there is insufficient difference between the intervention and control arms for tested primary outcomes to reject the null hypothesis. In this chapter, the authors explore the prevalence of null effects in different domains where clinical trials have been undertaken. Using a case study trial of specialist home visiting intended to prevent maltreatment, they explore what may contribute to null effects in trials. Such null effects include occasions where differences in effect are found between early stages of research, where the potential efficacy of a new approach shows promise, and later phases where interventions may be delivered at scale. The authors look at what may be learnt from trials where a null effect is concluded for both future design and delivery of a new intervention or service and for future evaluation.

Keywords: Null effects; Randomised controlled trials; Intervention evaluation; Explanatory trials; Pragmatic trials; Children's social care (search for similar items in EconPapers)
Date: 2025
ISBN: 9781035327140
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