Insights into Ionizing-Radiation-Resistant Bacteria S-Layer Proteins and Nanobiotechnology for Bioremediation of Hazardous and Radioactive Waste

Kais Ghedira, Houcemeddine Othman, Taieb Saied, Zouhair Majdi Baccar, Faouzi Hosni, Ahmed Hichem Hamzaoui, Kaliannan Thamaraiselvi, Hafedh Abdelmelek, Najet Srairi, Maria Clara Costa and Haitham Sghaier

A chapter in Management of Hazardous Wastes from IntechOpen

Abstract: S-layers are crystalline arrays formed by proteinaceous subunits that cover the outer surface of many different kinds of microorganisms. This "proteinaceous cover" is particularly important in the case of ionizing-radiation-resistant bacteria (IRRB) that might be used in bioremediating hazardous and radioactive wastes (HRW). Despite the exponential growth in the number of comparative studies and solved proteic crystal structures, the proteic networks, diversity, and bioremediation-useful structural properties of IRRB S-layers remain unknown. Here, aided by literature, a tentative model of Deinococcus radiodurans R1 S-layer proteins (SLPs) and the network of its main constituents were proposed. The domain analysis of this network was performed. Moreover, to show the diversity of IRRB S-layers, comparative genomics and computer modeling experiments were carried out. In addition, using in silico modeling, assisted by previously published data, the outermost exposed segments of D. radiodurans SlpA (surface layer protein A) that were predicted to interact with uranium were mapped. The combination of data and results pointed to various prospective applications of IRRB S-layers in nanobiotechnology for bioremediation of radioactive waste.

Keywords: bioremediation; ionizing-radiation-resistant bacteria; nanobiotechnology; radioactive waste; S-layer proteins; uranium (search for similar items in EconPapers)
JEL-codes: Q53 (search for similar items in EconPapers)
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Persistent link: https://EconPapers.repec.org/RePEc:ito:pchaps:104201

DOI: 10.5772/64146

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