Clinical Trials in Pregnant Women with Preeclampsia

Leonel Garcia Benavides, Diego Hernandez Molina, Jessica Lucia Barajas Vega, Sylvia Elena Totsuka Sutto, Fernando Grover Paez, Francisco Javier Hernandez Mora, Ernesto Javier Ramirez Lizardo, Sara Pascoe Gonzalez, David Cardona Muller and Ernesto German Cardona-Munoz

A chapter in Clinical Trials in Vulnerable Populations from IntechOpen

Abstract: Preeclampsia (PE) is the leading cause of preterm birth by medical indication when associated with premature detachment of placenta normoinserta, and Intrauterine growth restriction (IUGR) is associated with high perinatal morbidity and mortality and long-term sequelae. The main problem of PE is threefold: the diagnostic difficulty, the complicated interrelationship of the pathophysiological processes, and the vulnerability of the maternal-fetal binomial to the therapeutic interventions. The approach for management with PE is preventing its late occurrence in pregnancy. The key to preventing PE is knowledge of the factors that trigger the pathophysiological processes that culminate in the presentation of PE. Understanding the developmental characteristics of the placenta in pregnancy at high risk for PE is essential for understanding the pathophysiology and developing strategies for prevention. When deciding that the population of study is a group of pregnant women, the first ethical criteria that need to be reviewed are those aimed at the protection of the fetus. There are no specific guidelines on how to assess fetal well-being during pregnancy routinely in the clinic, and this deficiency is shifted to clinical research with pregnant women.

Keywords: preeclampsia; eclampsia; pregnancy induced-hypertension; complications in pregnancy women (search for similar items in EconPapers)
JEL-codes: I11 (search for similar items in EconPapers)
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Persistent link: https://EconPapers.repec.org/RePEc:ito:pchaps:116442

DOI: 10.5772/intechopen.70185

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