Bayesian Inference of Gene Regulatory Network

Xi Chen and Jianhua Xuan

A chapter in Bayesian Inference on Complicated Data from IntechOpen

Abstract: Gene regulatory networks (GRN) have been studied by computational scientists and biologists over 20 years to gain a fine map of gene functions. With large-scale genomic and epigenetic data generated under diverse cells, tissues, and diseases, the integrative analysis of multi-omics data plays a key role in identifying casual genes in human disease development. Bayesian inference (or integration) has been successfully applied to inferring GRNs. Learning a posterior distribution than making a single-value prediction of model parameter makes Bayesian inference a more robust approach to identify GRN from noisy biomedical observations. Moreover, given multi-omics data as input and a large number of model parameters to estimate, the automatic preference of Bayesian inference for simple models that sufficiently explain data without unnecessary complexity ensures fast convergence to reliable results. In this chapter, we introduced GRN modeling using hierarchical Bayesian network and then used Gibbs sampling to identify network variables. We applied this model to breast cancer data and identified genes relevant to breast cancer recurrence. In the end, we discussed the potential of Bayesian inference as well as Bayesian deep learning for large-scale and complex GRN inference.

Keywords: gene regulatory network; data integration; Bayesian inference; Gibbs sampling; breast cancer (search for similar items in EconPapers)
JEL-codes: C60 (search for similar items in EconPapers)
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.intechopen.com/chapters/68821 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ito:pchaps:201010

DOI: 10.5772/intechopen.88799

Access Statistics for this chapter

More chapters in Chapters from IntechOpen
Bibliographic data for series maintained by Slobodan Momcilovic ().