Case Study: Occupational Health Risks from Crystalline Silica

Louis Anthony Cox
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Louis Anthony Cox: Cox Associates and University of Colorado

Chapter Chapter 4 in Quantitative Risk Analysis of Air Pollution Health Effects, 2021, pp 79-115 from Springer

Abstract: Abstract Chapter 3 pointed out that chronic inflammation mediates an extraordinarily wide range of diseases. Recent progress in understanding intracellular inflammasome assembly, priming, activation, cytokine signaling, and interactions with mitochondrial reactive oxygen species (ROS), lysosome disruption, cell death, and prion-like polymerization and spread of inflammasomes among cells, has potentially profound implications for dose-response modeling. This chapter and Chaps. 5 and 6 further discuss biological mechanisms of exposure concentration and duration thresholds for NLRP3 inflammasome-mediated inflammatory responses, and develop and apply simple biomathematical models of the onset of exposure-related tissue-level chronic inflammation and resulting disease risks. This chapter focuses on respirable crystalline silica (RCS) and lung cancer risk as an example. It proposes an inflammation-mediated two-stage clonal expansion (I-TSCE) model of RCS-induced lung cancer that explains why relatively low estimated concentrations of RCS (e.g.,

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:spr:isochp:978-3-030-57358-4_4

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DOI: 10.1007/978-3-030-57358-4_4

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