An Optimal Response-Adaptive Design for Multi-treatment Clinical Trials with Circular Responses

Taranga Mukherjee (), Rahul Bhattacharya () and Atanu Biswas ()
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Taranga Mukherjee: University of Calcutta
Rahul Bhattacharya: University of Calcutta
Atanu Biswas: Indian Statistical Institute

A chapter in Applied Advanced Analytics, 2021, pp 147-156 from Springer

Abstract: Abstract Circular or directional outcomes are natural responses in many clinical trials (e.g. orthopedics, ophthalmology, sports medicine). Traditionally, clinical trials use equal allocation throughout the trial without utilizing the information contained in the sequentially observed responses in the running trial. Adaptive allocation designs are data-dependent alternatives to assign a greater number of subjects to the better performing treatments using the available data of the running trial in a convenient way. However, adaptive designs for circular responses are rare and, therefore, in the current work, we develop a multi-treatment response-adaptive randomization for circular treatment outcomes considering both the ethics and efficiency requirements. Apart from assessing the proposed allocation design empirically, the applicability of the design in real clinical trials is also enumerated from a practitioner’s viewpoint.

Keywords: Circular response; Von Mises distribution; Circular distance; Cataract surgery (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:spr:prbchp:978-981-33-6656-5_13

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DOI: 10.1007/978-981-33-6656-5_13

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