Continuous Twin-Screw Granulation Processing

Uttom Nandi, Tumpa Dey and Dennis Douroumis ()
Additional contact information
Uttom Nandi: University of Greenwich
Tumpa Dey: University of Greenwich
Dennis Douroumis: University of Greenwich

A chapter in Optimization of Pharmaceutical Processes, 2022, pp 135-169 from Springer

Abstract: Abstract Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest for the development of oral dosage forms. The technology has evolved rapidly due to the flexibility of the equipment design, the selection of the process variables and the wide range of processed materials. Most importantly, TSG offers the benefits of both batch and continuous manufacturing for pharmaceutical products accompanied with excellent process control, high product quality which can be achieved through the implementation of quality by design (QbD) approaches and the integration of process analytical technologies (PAT). Here we present the basic concepts of the various twin-screw granulation techniques and present in detail their advantages and disadvantages. In addition, we discuss the detail of the instrumentation used for TSG and how the critical processing parameters (CPPs) affect the critical quality attributes (CQAs) of the produced granules. Finally, we present recent advances in TSG continuous manufacturing including paradigms of QbD approaches coupled with PAT monitoring for granule optimisation and process understanding.

Keywords: 3D printing; Bioresorbable polymers; Stents; Regulatory; Scaffolds; Cardiovascular diseases (search for similar items in EconPapers)
Date: 2022
References: Add references at CitEc
Citations:

There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:spochp:978-3-030-90924-6_6

Ordering information: This item can be ordered from
http://www.springer.com/9783030909246

DOI: 10.1007/978-3-030-90924-6_6

Access Statistics for this chapter

More chapters in Springer Optimization and Its Applications from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().