Ultrasound for Improved Encapsulation and Crystallization with Focus on Pharmaceutical Applications

Chinmayee Sarode, Yashraj Jagtap and Parag Gogate ()
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Chinmayee Sarode: Institute of Chemical Technology
Yashraj Jagtap: Institute of Chemical Technology
Parag Gogate: Institute of Chemical Technology

A chapter in Optimization of Pharmaceutical Processes, 2022, pp 193-229 from Springer

Abstract: Abstract A growing need for developing novel technologies for obtaining better quality products with enhanced process efficiency has created promise for application of ultrasound in the area of food and pharmaceutical processing. This chapter offers discussion on the governing mechanisms for the improvement based on the use of ultrasound, different ultrasonic reactor configurations, as well as the selection of operating conditions for the specific applications of encapsulation and crystallization. The effects of ultrasound during the processing such as liquid circulation, turbulence, and local hot spots drive the observed intensification. Analysis of reactor designs revealed that there is a need for development of continuous reactors with usage of a large number of transducers so as to give the desired processing benefits based on uniform distribution of cavitational activity. It has been also elucidated that application of ultrasound under the desired conditions can give advantages such as greater control over particle size, enhanced solubility of drugs, controlled crystallization, and production of nanomaterials. Overall, this chapter has clearly demonstrated the advantages of ultrasound and highlights the need for specific efforts required for exploitation at commercial scale.

Keywords: Encapsulation; Crystallization; Ultrasound; Particle size; Uniform distribution; Drugs and intermediates (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:spr:spochp:978-3-030-90924-6_8

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DOI: 10.1007/978-3-030-90924-6_8

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