Developments in Statistical Evaluation of Clinical Trials

Edited by Kees van Montfort (), Johan Oud () and Wendimagegn Ghidey ()

in Springer Books from Springer

Date: 2014
Edition: 2014
ISBN: 978-3-642-55345-5
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Chapters in this book:

Ch Chapter 1 Statistical Models and Methods for Incomplete Data in Randomized Clinical Trials

Michael A. McIsaac and Richard J. Cook

Ch Chapter 10 Different Methods to Analyse the Results of a Randomized Controlled Trial with More Than One Follow-Up Measurement

Jos W. R. Twisk

Ch Chapter 11 Statistical Methods for the Assessment of Clinical Relevance

Meinhard Kieser

Ch Chapter 12 Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses

Richard J. Cook and Ker-Ai Lee

Ch Chapter 13 Statistical Validation of Surrogate Markers in Clinical Trials

Ariel Alonso, Geert Molenberghs and Gerard van Breukelen

Ch Chapter 14 Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine

Shigeyuki Matsui, Takahiro Nonaka and Yuki Choai

Ch Chapter 15 Dose-Finding Methods for Two-Agent Combination Phase I Trials

Akihiro Hirakawa and Shigeyuki Matsui

Ch Chapter 16 Multi-state Models Used in Oncology Trials

Birgit Gaschler-Markefski, Karin Schiefele, Julia Hocke and Frank Fleischer

Ch Chapter 17 Review of Designs for Accommodating Patients’ or Physicians’ Preferences in Randomized Controlled Trials

Afisi S. Ismaila and Stephen D. Walter

Ch Chapter 18 Dose Finding Methods in Oncology: From the Maximum Tolerated Dose to the Recommended Phase II Dose

Xavier Paoletti and Adélaide Doussau

Ch Chapter 2 Bayesian Decision Theory and the Design and Analysis of Randomized Clinical Trials

Andrew R. Willan

Ch Chapter 3 Designing Multi-arm Multi-stage Clinical Studies

Thomas Jaki

Ch Chapter 4 Statistical Approaches to Improving Trial Efficiency and Conduct

Janice Pogue, P. J. Devereaux and Salim Yusuf

Ch Chapter 5 Competing Risks and Survival Analysis

Kees van Montfort, Peter Fennema and Wendimagegn Ghidey

Ch Chapter 6 Recent Developments in Group-Sequential Designs

James M. S. Wason

Ch Chapter 7 Statistical Inference for Non-inferiority of a Diagnostic Procedure Compared to an Alternative Procedure, Based on the Difference in Correlated Proportions from Multiple Raters

Hiroyuki Saeki and Toshiro Tango

Ch Chapter 8 Design and Analysis of Clinical Trial Simulations

Kazuhiko Kuribayashi

Ch Chapter 9 Causal Effect Estimation and Dose Adjustment in Exposure-Response Relationship Analysis

Jixian Wang

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DOI: 10.1007/978-3-642-55345-5

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