Assessing Possible Late Treatment Effects Early: The Diabetic Retinopathy Study Experience

Fred Ederer

Chapter Case 1 in Data Monitoring in Clinical Trials, 2006, pp 55-63 from Springer

Abstract: Abstract The Diabetic Retinopathy Study (DRS) assessed the ability of photocoagulation to delay or prevent severe visual loss in people with proliferative diabetic retinopathy. Benefit was detected early, but there where concerns about the possibility of late adverse effects. Calculations using projected blindness and death rates reassured the data monitoring committee that even large late adverse affects would not offset the early benefit already observed.

Keywords: Diabetic Retinopathy; Proliferative Diabetic Retinopathy; Case Study Approach; Data Monitoring Committee; Severe Visual Loss (search for similar items in EconPapers)
Date: 2006
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-0-387-30107-5_5

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DOI: 10.1007/0-387-30107-0_5

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