At the Interface of Statistics and Medicine: Conflicting Paradigms

Vera S. Byers and Kenneth Gorelick
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Vera S. Byers: Allergene Inc.
Kenneth Gorelick: Stanford University

Chapter 7 in Festschrift for Lucien Le Cam, 1997, pp 107-134 from Springer

Abstract: Abstract The association of Professor Le Cam with clinical investigators started in 1973, when he collaborated in the design of a clinical trial using an immunotherapeutic agent in patients with osteogenic sarcoma. Collaborations between statisticians and clinicians started quite early—British clinicians and statisticians were publishing studies together in the 1950’s. However before the 1960’s such collaborations were sporadic, and certainly not mandatory. By 1973 they were quite pervasive, so the history of Professor Le Cam’s involvement in clinical research probably mirrored closely the development of collaborations between clinical researchers and statisticians. Those of us in clinical research have seen the growing influence of statisticians. The statistical-clinical relationship is an evolving one and remains, at times, rather rocky. This friendly antagonism is likely due to the institutional differences in perception and priorities between the two professions.

Keywords: Angina Pectoris; England Journal; Interim Analysis; Placebo Effect; Pneumocystis Carinii Pneumonia (search for similar items in EconPapers)
Date: 1997
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Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-1-4612-1880-7_7

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DOI: 10.1007/978-1-4612-1880-7_7

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