The Mechanism of Actin-Filament Assembly and Cross-Linking

Thomas D. Pollard, Ueli Aebi, John A. Cooper, Marshall Elzinga, Walter E. Fowler, Linda M. Griffith, Ira M. Herman, John Heuser, Gerhard Isenberg, Daniel P. Kiehart, Janelle Levy, Susan MacLean-Fletcher, Pamela Maupin, Mark S. Mooseker, Marschall Runge, P. Ross Smith and Peter Tseng
Additional contact information
Thomas D. Pollard: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Ueli Aebi: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
John A. Cooper: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Marshall Elzinga: Brookhaven National Laboratories, Biology Division
Walter E. Fowler: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Linda M. Griffith: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Ira M. Herman: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
John Heuser: Washington University School of Medicine, Department of Physiology and Biophysics
Gerhard Isenberg: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Daniel P. Kiehart: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Janelle Levy: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Susan MacLean-Fletcher: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Pamela Maupin: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
Mark S. Mooseker: Yale University, Department of Biology
Marschall Runge: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy
P. Ross Smith: New York University School of Medicine, Department of Cell Biology
Peter Tseng: The Johns Hopkins University School of Medicine, Department of Cell Biology and Anatomy

Chapter 2 in Cell and Muscle Motility, 1982, pp 15-44 from Springer

Abstract: Abstract Actin is one of the major proteins in eukaryotic cells, and actin filaments are the major structural element of both the contractile apparatus and the “cyto-skeleton” of most cells. In their role as a contractile protein, filaments of actin are thought to interact with myosin to generate the force for cellular motility, much like they do in muscle contraction. The role of actin as a structural protein is less well defined, but probably no less important. The general idea is that the cytoplasm contains a three-dimensional network of actin filaments that can be cross-linked to form a gel. This network forms an internal scaffolding that traps the organelles (see Mast, 1926), distributes local contractile forces throughout the cytoplasm to the cell surface, and may also provide a scaffolding for certain enzyme systems (Clark and Masters, 1975).

Keywords: Actin Filament; Actin Polymerization; Gelation Protein; Actin Monomer; Acanthamoeba Castellanii (search for similar items in EconPapers)
Date: 1982
References: Add references at CitEc
Citations:

There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:spr:sprchp:978-1-4684-4037-9_2

Ordering information: This item can be ordered from
http://www.springer.com/9781468440379

DOI: 10.1007/978-1-4684-4037-9_2

Access Statistics for this chapter

More chapters in Springer Books from Springer
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().