Sample Size Reestimation

Wenping Wang and Andreas Krause
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Wenping Wang: Pharsight Corporation
Andreas Krause: Novartis Pharma AG

Chapter 15 in Applied Statistics in the Pharmaceutical Industry, 2001, pp 375-396 from Springer

Abstract: Abstract The number of subjects is an important design parameter in clinical trials. The key information when planning the sample size is the postulated effect and its variation. The effect size may come from prior trials, from literature review, or quite often from the best guess by the investigator.

Keywords: Posterior Distribution; Markov Chain Monte Carlo; Gibbs Sampling; Markov Chain Monte Carlo Method; Royal Statistical Society (search for similar items in EconPapers)
Date: 2001
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DOI: 10.1007/978-1-4757-3466-9_15

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